A study of the growth of needle crystals of monosodium urate was undertaken with the aim of finding inhibitors which might be able to prevent the acute gout attack. Rates of crystal growth at various levels of supersaturation are described. Two potent crystal growth inhibitors, Bismarck brown and methylene blue, were found. They are shown to be adsorbed onto monosodium urate. THAM was found to accelerate needle crystal growth.
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Allen et al. (1965) studied this question.
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