What is the clinical evidence from this study?

Study design: RCT. Population: Pre-hypertension to stage 1 hypertension (n=40). Intervention: Resistance exercise vs. Aerobic exercise. Primary outcome: Central pulse wave velocity (time × sex × mode interaction) (p=0.001).

What does this research mean for the field?

Moderate-intensity resistance exercise significantly increases central arterial stiffness in men but not in women, while producing greater reductions in diastolic blood pressure in hypertensive women compared to aerobic exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To evaluate sex differences in resting hemodynamics and arterial stiffness following 4 weeks of moderate-intensity aerobic versus resistance exercise training in unmedicated individuals with pre-hypertension to stage 1 hypertension.

January 1, 2011Biology of Sex DifferencesOpen Access

Sex differences in resting hemodynamics and arterial stiffness following 4 weeks of resistance versus aerobic exercise training in individuals with pre-hypertension to stage 1 hypertension

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Key result

Resistance exercise increases male central arterial stiffness but lowers female diastolic BP more than aerobic exercise.

P=0.001
n=40

Why the study?

Hypertension exhibits sexual dimorphism, and while aerobic exercise prevents and treats hypertension, resistance exercise is not recommended to treat hypertension, leaving potential sex differences between aerobic and resistance exercise uncertain.

Does resistance exercise compared to aerobic exercise improve hemodynamics and arterial stiffness differently in men and women with pre-hypertension to stage 1 hypertension?

Population

40 moderately active, pre-hypertensive or stage 1 essential hypertensive participants aged 40 to 60 years

Comparison

Resistance exercise vs aerobic exercise stratified by sex

Design

Randomized trial

Follow-up

4 weeks

Authors

SCScott R. CollierAppalachian State University VFVincent FrechetteSUNY Upstate Medical University KSKathryn SandbergGeorgetown University

Discussion

Member takes

Implication

RE may benefit women more than men for HTN without raising arterial stiffness; leaves open larger trials before sex-specific recommendations.

Key Points

To evaluate sex differences in resting hemodynamics and arterial stiffness following 4 weeks of moderate-intensity aerobic versus resistance exercise training in unmedicated individuals with pre-hypertension to stage 1 hypertension.
Randomized 40 moderately active men and women aged 40 to 60 years with pre-hypertension or stage 1 essential hypertension into four groups: male aerobic exercise, male resistance exercise, female aerobic exercise, and female resistance exercise.
Administered moderate-intensity exercise training 3 days per week for 4 weeks.
Measured resting hemodynamic parameters, arterial stiffness, and blood flow before and after the 4-week training period.
Men exhibited a significant increase in central pulse wave velocity following resistance exercise (12 ± to 13.9 ± m/s), whereas women showed no significant change (9.2 ± to 9.6 ± m/s).
Resistance exercise induced significantly larger increases in peak blood flow compared to aerobic exercise in both females (15 ± to 20 ± vs. 17.5 ± to 19.5 ± ml/100ml/min) and males (19 ± to 24 ± vs. 21 ± to 25 ± ml/100ml/min).
Women achieved greater systolic and diastolic blood pressure reductions following resistance exercise compared to aerobic exercise, whereas men demonstrated comparable blood pressure reductions across both exercise modalities.

Study Design

Type

RCT (n=40)

Blinding

Single-blind

Randomization

Randomized

Multicenter

Structured PICO

Does resistance exercise compared to aerobic exercise improve hemodynamics and arterial stiffness differently in men and women with pre-hypertension to stage 1 hypertension?

Population

40 moderately active, unmedicated adults aged 40 to 60 years with pre-hypertension or stage 1 hypertension, randomized to 4 weeks of aerobic or resistance exercise.

Intervention

Resistance exercise (RE) training at moderate intensity, 3 days/week for 4 weeks.

Comparator

Aerobic exercise (AE) training at moderate intensity, 3 days/week for 4 weeks.

Outcome

Hemodynamic, vascular and blood-flow data (including central pulse wave velocity, peak blood flow, and blood pressure) before and after 4 weeks of exercise training.surrogate

Main Result

p-value: p=0.001

Moderate-intensity resistance training may be a more favorable treatment option for women with hypertension due to greater decreases in diastolic BP and no concomitant increases in arterial stiffness compared to men.

Limitations

Small sample size (n=40)
Short duration of the exercise intervention (4 weeks)
Significant age difference between male and female cohorts (women were 8 years older on average to account for postmenopausal status)
Lack of a non-exercising control group

Cite This Study

Collier et al. (2011) conducted an RCT in Pre-hypertension to stage 1 hypertension (n=40). Resistance exercise vs. Aerobic exercise was evaluated on Central pulse wave velocity (time × sex × mode interaction) (p=0.001). Four weeks of moderate-intensity resistance exercise significantly increased central arterial stiffness in men but not in women, while producing greater decreases in diastolic blood pressure in women compared to aerobic exercise.

synapsesocial.com/papers/6aa84e69e43c8e8f383e15c5 https://doi.org/10.1186/2042-6410-2-9

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Implication

RE may benefit women more than men for HTN without raising arterial stiffness; leaves open larger trials before sex-specific recommendations.

Sex differences in resting hemodynamics and arterial stiffness following 4 weeks of resistance versus aerobic exercise training in individuals with pre-hypertension to stage 1 hypertension

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Sex differences in resting hemodynamics and arterial stiffness following 4 weeks of resistance versus aerobic exercise training in individuals with pre-hypertension to stage 1 hypertension

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider