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A series of six new 3-(1-hydroxynaphthalen-2-yl)-1-aryl-1H-pyrazole-4-carbaldehyde derivatives were synthesized by Vilsmeier-Haack reaction of phenyl hydrazones.The new compounds were characterized by spectral studies and elemental analysis.Synthesized compounds were evaluated in vitro for their antimicrobial and antioxidant susceptibilities.The results suggest that the compounds with methyl and methoxy substitutions in the aromatic ring have good in vitro antimicrobial activities and those with methyl, methoxy and no substitutions possess promising DPPH and hydroxyl free radical scavenging abilities.
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Gurunanjappa et al. (2017) studied this question.
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