THE rapid changes which occur during the reproductive cycle make the ovary an ideal subject for investigations designed to correlate structure and function. During the four-day period of this cycle in the rat, graafian follicles grow to maturity, rupture, and in the subsequent cycle become reorganized into mature corpora lutea which later degenerate. The histological features and physiological concomitants of these ovarian events are well known for the rat (Long and Evans, 1922; Allen, Hisaw and Gardner, 1939; Boling, Blandau, Soderwall and Young, 1941), and an impressive amount of circumstantial evidence relates these events to the biochemical aspects of steroid hormone metabolism (cf. Allen, Hisaw and Gardner, 1939; Doisy, 1939, 1943). Thus a substantial background of information exists which may be used as a cross-check on the results of any new procedure.
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Dempsey et al. (1943) studied this question.