Key result
Previous cardiac surgery is not linked to significantly higher operative mortality versus first-time isolated AVR.
Why the study?
Previous cardiac surgery is a risk factor for operative mortality in reoperative AVR and may be influenced by institutional surgical volume.
Does previous cardiac surgery increase operative mortality and reduce survival in patients undergoing isolated aortic valve replacement?
Cohort (n=854)
No
Does previous cardiac surgery increase operative mortality and reduce survival in patients undergoing isolated aortic valve replacement?
Absolute Event Rate: 12.5% vs 3.6%
p-value: p=0.08
Previous cardiac surgery is not an independent predictor of operative mortality or long-term survival in patients undergoing isolated aortic valve replacement when adjusting for baseline covariates.
Prior surgery was not linked to higher operative mortality in matched isolated AVR; leaves open effects on survival and needs prospective confirmation.
INTRODUCTION: Previous cardiac surgery (PCS) is a risk factor for operative mortality in pa-tients undergoing reoperative aortic valve replacement (AVR) and may be influenced by the volume of patients in each center. The aim of this study was to evaluate the results of AVR in patients with previous cardiac surgery in a low volume cardiac center (400 cases per year). METHODS: Between January 2006 and December 2016, 854 patients underwent isolated AVR surgery at our institution. Of these, 70 had PCS. Propensity match (PM) was per-formed to balance basal covariates. Operative mortality and survival were the primary outcomes. RESULTS: The PCS and first-time surgery (FTS) groups had significant differences in base-line characteristics (PCS group were older, higher incidence of hypertension, endocarditis, NYHA III/IV, lower LVEF, higher creatinine and higher EuroSCORE). In the unmatched population, patients with PCS had higher operative mortality (17.1% vs. 4.6%, P=0.001). In the PM groups, this difference was not significant (12.5% and 3.6%, P=0.08). The only independent predictors for operative mortality found in the PCS group were age and fe-male gender. Age and diabetes were identified as the only independent predictors of sur-vival. CONCLUSION: PCS was not a predictor for operative mortality nor long-term survival in pa-tients undergoing isolated aortic valve replacement.
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Dayan et al. (2019) conducted a cohort in Isolated aortic valve replacement (n=854). Previous cardiac surgery vs. First-time surgery was evaluated on Operative mortality (p=0.08). Previous cardiac surgery did not significantly increase operative mortality compared to first-time surgery in propensity-matched patients undergoing isolated AVR (12.5% vs 3.6%, P=0.08).
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