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May 1, 2006CirculationOpen Access

Akt Signaling and Growth of the Heart

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Key result

Akt1 signaling promotes physiological cardiac growth while inhibiting pathological hypertrophy.

Why the study?

The molecular regulation of physiological cardiac growth is less understood compared to pathological heart growth.

Design

Editorial discussing Akt1 signaling in cardiac growth

Authors

Kenneth Walsh
Kenneth WalshRutgers, The State University of New Jersey

Discussion

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Overview

Distinguishes growth patterns to refine clinical hypertrophy assessment; leaves open molecular targets for selective intervention.

PICO

P
Population
Cardiac hypertrophy
E
Exposure / Comparator
Akt1 signaling

This editorial highlights the role of Akt1 signaling in promoting physiological cardiac growth and inhibiting pathological hypertrophy.

Cite This Study

Kenneth Walsh (2006) conducted an editorial in Cardiac hypertrophy. Akt1 signaling was evaluated. Akt1 signaling plays a role in the promotion of physiological cardiac growth and the inhibition of pathological hypertrophy.

synapsesocial.com/papers/6aa85aaa8db0aff0e03e155chttps://doi.org/10.1161/circulationaha.106.615138
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure2001 · 439 citations
  2. 2Akt induces enhanced myocardial contractility and cell size <i>in vivo</i> in transgenic mice2002 · 462 citations
  3. 3Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice2002 · 512 citations
  4. 4Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy2003 · 773 citations
  5. 5Sex modifies exercise and cardiac adaptation in mice2004 · 201 citations