Key result
High-level peak-and-decline VIS trajectory linked to ~167% higher 30-day mortality versus low steady decline.
Why the study?
The authors hypothesized that vasoactive-inotropic score (VIS) trajectories after cardiac surgery independently associate with 30-day all-cause mortality and organ dysfunction in postcardiotomy cardiogenic shock.
Does the early vasoactive-inotropic score (VIS) trajectory predict 30-day all-cause mortality in postcardiotomy cardiogenic shock patients?
Cohort (n=1,654)
No
Does the early vasoactive-inotropic score (VIS) trajectory predict 30-day all-cause mortality in postcardiotomy cardiogenic shock patients?
Hazard Ratio: 2.67 (95% CI 1.2–5.97)
Early 72-hour vasoactive-inotropic score trajectories can stratify postcardiotomy cardiogenic shock patients, with high-level peak-and-decline trajectories predicting higher 30-day mortality and worse organ dysfunction.
High-level peak-and-decline VIS trajectory was associated with higher mortality; leaves open whether trajectory-based stratification improves outcomes in postcardiotomy shock.
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Su et al. (2026) conducted a cohort in postcardiotomy cardiogenic shock (n=1,654). High-level peak-and-decline vasoactive-inotropic score trajectory (class 2) vs. Low-level steady decline trajectory (class 4) was evaluated on 30-day all-cause mortality after ICU admission (HR 2.67, 95% CI 1.20-5.97). A high-level peak-and-decline vasoactive-inotropic score trajectory increased 30-day mortality compared with a low-level steady decline trajectory (HR 2.67; 95% CI 1.20-5.97).
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