Key result
Betaxolol and atenolol suppress adrenaline-induced but not digitalis-induced ventricular arrhythmias in canine models.
Why the study?
Does betaxolol suppress ventricular arrhythmias in canine models compared to atenolol?
Does betaxolol suppress ventricular arrhythmias in canine models compared to atenolol?
Betaxolol and atenolol effectively suppress adrenaline-induced but not digitalis-induced ventricular arrhythmias in canine models, suggesting clinical utility for arrhythmias related to increased sympathetic tone.
May guide beta-blocker selection for sympathetic arrhythmias in models; leaves open translation to digitalis toxicity or human use.
Antiarrhythmic effects of a new beta 1 selective adrenoceptor blocker, betaxolol, were examined in comparison with those of atenolol using two canine ventricular arrhythmia models (adrenaline arrhythmia and digitalis arrhythmia). Both betaxolol and atenolol suppressed adrenaline arrhythmia, and the minimum effective plasma concentration of betaxolol for this arrhythmia model was determined to be less than 10 ng/ml. However, on digitalis arrhythmia, both beta blockers were ineffective, even though the high doses used in these experiments, 3 mg/kg for betaxolol and 5 mg/kg for atenolol, showed significant hypotensive effects. The present results suggest that betaxolol and atenolol may be expected to be clinically effective on arrhythmias related to increased sympathetic tone.
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MITSUHASHI et al. (1987) studied Canine ventricular arrhythmias. Betaxolol vs. Atenolol was evaluated on Suppression of adrenaline and digitalis arrhythmias. Betaxolol and atenolol suppressed adrenaline-induced ventricular arrhythmias in canine models, but both were ineffective against digitalis-induced arrhythmias despite significant hypotensive effects.
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