Why the study?
Does acebutolol alter hemodynamics and cardiac rhythm in anesthetized dogs?
Population
10 adult mongrel dogs weighing 12-17 kg, anesthetized with pentobarbital sodium and 33% nitrous oxide in…
Comparison
Acebutolol 1 mg/kg intravenously every 5-7… vs Baseline before acebutolol administration.
Design
Preclinical
Follow-up
Acute (measurements taken 5-7 minutes after each dose)
Authors
Loading...
Caution against high-dose use in low-contractility patients; animal data leaves open human translation for angina or tachyarrhythmias.
Does acebutolol alter hemodynamics and cardiac rhythm in anesthetized dogs?
Acebutolol dose-dependently decreases myocardial contractility and oxygen consumption while exhibiting antiarrhythmic effects, suggesting clinical utility for angina and tachyarrhythmia but with a risk of heart failure at high doses.
Shimizu et al. (1976) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: