Why the study?
Does long-term oral acebutolol prevent postischaemic ventricular fibrillation in a canine model of acute coronary occlusion?
Population
42 open chest anaesthetised dogs undergoing acute occlusions of the proximal left circumflex coronary…
Comparison
Acebutolol 3 mg/kg oral twice daily for five days vs Matching oral placebo for five days, or no…
Design
Preclinical, randomly allocated, given blindly
Follow-up
60 minutes post-occlusion
Authors
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Supports preclinical testing of acebutolol for ischemia-induced VF; leaves open translation to clinical post-MI arrhythmia prevention.
Does long-term oral acebutolol prevent postischaemic ventricular fibrillation in a canine model of acute coronary occlusion?
In a canine model of acute coronary occlusion, long-term oral acebutolol significantly reduced the incidence of ischemia-induced ventricular fibrillation.
Puddu et al. (1986) studied this question.
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