Key result
Propranolol prolonged time to fibrillation during transient ischaemia from 122 to 262 seconds (p < 0.001) by attenuating tachycardia, but lacked protective effect during prolonged ischaemia.
Why the study?
Does propranolol prevent ischaemic ventricular fibrillation in a pig model of ischaemia?
Population
Anaesthetized, open-chest pigs in a model of ischaemia
Comparison
Propranolol with or without isoprenaline infusion vs Control conditions
Design
Preclinical
Follow-up
up to >60 minutes of ischaemia
Authors
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Supports rate-dependent VF delay in transient ischaemia models; leaves open independent effects during prolonged infarction.
Does propranolol prevent ischaemic ventricular fibrillation in a pig model of ischaemia?
Absolute Event Rate: 262% vs 122%
p-value: p=< 0.001
Propranolol prevents ischaemic ventricular fibrillation in a pig model primarily through its heart rate-lowering effect, but does not offer effective protection independent of heart rate control during the first hour of infarction.
J.-F. Aupetit (1998) studied ischaemic ventricular fibrillation. propranolol vs. control / isoprenaline was evaluated on Time to fibrillation (p=< 0.001). Propranolol prolonged time to fibrillation during transient ischaemia from 122 to 262 seconds (p < 0.001) by attenuating tachycardia, but lacked protective effect during prolonged ischaemia.
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