Why the study?
Does adaptation to the laboratory or propranolol administration affect the latency to ventricular fibrillation following coronary artery occlusion in conscious pigs?
Population
45 unanesthetized farm pigs undergoing abrupt occlusion of the left anterior descending coronary artery
Comparison
Adaptation to the laboratory and/or… vs Control values (unadapted animals, no propranolol)
Design
Preclinical
Authors
Loading...
Reducing acute stress may delay VF onset in ischemic models; leaves open propranolol dosing effects on arrhythmia thresholds.
Does adaptation to the laboratory or propranolol administration affect the latency to ventricular fibrillation following coronary artery occlusion in conscious pigs?
In a conscious pig model of coronary occlusion, reduced psychological stress (adaptation) delayed ventricular fibrillation, whereas high-dose propranolol in unadapted animals accelerated it.
Skinner et al. (1975) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: