Key result
Prazosin and propranolol reduced the incidence of ventricular premature depolarizations and ventricular tachycardia during coronary occlusion in dogs, and significantly reduced ventricular fibrillation.
Why the study?
Does prazosin or propranolol reduce arrhythmias during coronary artery occlusion and re-perfusion in dogs and pigs?
Population
Open-chest dogs and pigs anaesthetized with pentobarbitone undergoing 30 min occlusion of the left anterior…
Design
Preclinical
Follow-up
45 minutes
Authors
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Hypothesis-generating in canine ischemia models; leaves open translation to other species or clinical use.
Does prazosin or propranolol reduce arrhythmias during coronary artery occlusion and re-perfusion in dogs and pigs?
Prazosin and propranolol exhibit species-dependent anti-arrhythmic efficacy during acute coronary occlusion and reperfusion, preventing ventricular fibrillation in dogs but not pigs.
Benfey et al. (1984) studied Coronary artery occlusion and reperfusion arrhythmias. Prazosin and propranolol vs. Control was evaluated on Incidence of ventricular premature depolarizations, ventricular tachycardia, and ventricular fibrillation. Prazosin and propranolol reduced the incidence of ventricular premature depolarizations and ventricular tachycardia during coronary occlusion in dogs, and significantly reduced ventricular fibrillation.
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