Why the study?
Does prazosin reduce ventricular fibrillation and improve survival in a canine model of post-myocardial infarction acute ischemia?
Does prazosin reduce ventricular fibrillation and improve survival in a canine model of post-myocardial infarction acute ischemia?
Blockade of alpha 1-adrenoceptors with prazosin prevents lethal ventricular arrhythmias and improves survival during acute ischemia in a post-infarction canine model.
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Wilber et al. (1987) studied Myocardial infarction with subsequent acute ischemia (n=32). Prazosin vs. Vehicle was evaluated on Incidence of ventricular fibrillation during the first 30 min of acute posterolateral ischemia (p=<0.05).
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