Why the study?
Does central beta-adrenergic receptor blockade with L-propranolol reduce ischemia-induced ventricular fibrillation vulnerability in a stressed pig model?
Population
Psychologically stressed pig model subjected to a maximum 15-minute left anterior descending coronary artery…
Comparison
Intracerebroventricular administration of… vs Intracerebroventricular administration of…
Design
Preclinical
Follow-up
15 minutes
Authors
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Hypothesis-generating for central beta-blockade in ischemia-induced VF; does not support clinical translation from this animal model.
Does central beta-adrenergic receptor blockade with L-propranolol reduce ischemia-induced ventricular fibrillation vulnerability in a stressed pig model?
Central beta-adrenergic blockade with L-propranolol reduces vulnerability to ischemia-induced ventricular fibrillation in a stressed pig model, suggesting a central nervous system mechanism.
Parker et al. (1990) studied this question.
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