Key result
Chronic propranolol treatment in rats with postinfarction heart failure did not improve systolic function and worsened left ventricular end-diastolic pressures (27 vs 20 mmHg).
Why the study?
Does propranolol improve left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure?
RCT (n=28)
randomized
Does propranolol improve left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure?
Absolute Event Rate: 27% vs 20%
In a rat model of postinfarction heart failure, chronic propranolol treatment failed to improve LV remodeling or systolic function and worsened diastolic function.
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Does not support propranolol in rat postinfarction HF; leaves open translation to other models or patients.
Litwin et al. (1999) conducted an RCT in postinfarction heart failure (n=28). Propranolol vs. No treatment was evaluated on Left ventricular end-diastolic pressure (mmHg). Chronic propranolol treatment in rats with postinfarction heart failure did not improve systolic function and worsened left ventricular end-diastolic pressures (27 vs 20 mmHg).
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