Why the study?
Does propranolol with or without exercise alter global and regional LV remodeling in rats after coronary occlusion and reperfusion?
Does propranolol with or without exercise alter global and regional LV remodeling in rats after coronary occlusion and reperfusion?
In a rat model of coronary occlusion and reperfusion, propranolol treatment led to altered LV remodeling including cavity dilation and reduced wall thickness, and suppressed exercise-induced myocardial hypertrophy.
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May worsen post-MI LV remodeling in rats; leaves open beta-blocker effects on human ventricular geometry post-reperfusion.
Oh et al. (1993) studied this question.
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