August 1, 1988CirculationOpen Access

Long-term propranolol administration alters myocyte and ventricular geometry in rat hearts with and without infarction.

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Why the study?

Does propranolol alter myocyte and ventricular geometry in adult rats with myocardial infarction?

Structured PICO

Does propranolol alter myocyte and ventricular geometry in adult rats with myocardial infarction?

Population

24 female Sprague-Dawley rats with myocardial infarction induced at 20-22 weeks of age

Intervention

Propranolol (750 mg/l) in drinking water for 5 weeks

Comparator

Water alone for 5 weeks

Outcome

Morphometric measurements of myocyte and ventricular geometry (septal area, myocyte length, cross-sectional area, volume, left ventricular cavity dimensions)surrogate

Propranolol blunts myocardial hypertrophy but increases left ventricular cavity dimensions in a rat model of myocardial infarction.

Discussion

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Implication

Propranolol may blunt hypertrophy while enlarging LV cavity in rat MI; leaves open translation to clinical remodeling effects.

Cite This Study

Fishbein et al. (1988) studied this question.

synapsesocial.com/papers/6a8592ad4f2eb4dbc91e6333 https://doi.org/10.1161/01.cir.78.2.369

View Full Paper

Ask AI

Bookmark

Long-term propranolol administration alters myocyte and ventricular geometry in rat hearts with and without infarction.

Structured PICO

Discussion

Implication

Cite This Study

Long-term propranolol administration alters myocyte and ventricular geometry in rat hearts with and without infarction.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider