Key result
Central tyrosine increases ventricular fibrillation after coronary occlusion, while adding propranolol reduces it to ~9%.
Why the study?
The role of the central nervous system in the development of ventricular fibrillation after coronary artery occlusion was not fully understood.
Does intracerebroventricular injection of tyrosine or propranolol affect the development of ventricular fibrillation after coronary artery occlusion in pigs?
Population
Conscious pigs with complete, permanent occlusion of the left anterior descending coronary artery
Comparison
Intracerebroventricular injections of tyrosine, tyrosine plus propranolol, or propranolol alone versus control
Design
Preclinical experimental study
Authors
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Central tyrosine loading may heighten ischemic VF risk via CNS catecholamines; leaves open whether this pathway merits human antiarrhythmic investigation.
Does intracerebroventricular injection of tyrosine or propranolol affect the development of ventricular fibrillation after coronary artery occlusion in pigs?
Absolute Event Rate: 100% vs 52%
Catecholamine synthesis in the central nervous system may play a significant role in the development of ventricular fibrillation following coronary artery occlusion.
Kirby et al. (1992) studied ventricular fibrillation after coronary artery occlusion. intracerebroventricular injection of tyrosine vs. control was evaluated on ventricular fibrillation. Intracerebroventricular administration of tyrosine increased ventricular fibrillation to 100% (vs 52% in controls) after coronary occlusion, while tyrosine plus propranolol reduced it to 9%.
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