Why the study?
Does cryogenic blockade of the frontocortical-brain stem pathway prevent ventricular fibrillation in conscious stressed pigs with myocardial ischemia?
Population
Conscious stressed pigs with left anterior descending coronary artery occlusion
Comparison
Cryogenic blockade of the forebrain, posterior… vs Blockade of control structures adjacent to these…
Design
Preclinical
Authors
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Suggests forebrain pathways modulate ischemia-induced VF; hypothesis-generating and requires human validation before any clinical consideration.
Does cryogenic blockade of the frontocortical-brain stem pathway prevent ventricular fibrillation in conscious stressed pigs with myocardial ischemia?
Functional blockade of the frontocortical-brain stem pathway prevents or delays ventricular fibrillation in a porcine model of myocardial ischemia and psychological stress.
Skinner et al. (1981) studied this question.
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