Why the study?
Does bilateral cryoblockade of the amygdala prevent ventricular fibrillation in psychologically stressed pigs during acute myocardial ischemia?
Population
Psychologically stressed pigs undergoing experimental coronary artery occlusion (n=18)
Comparison
Bilateral cryoblockade of the amygdala via… vs Cryoblockade in structures surrounding the…
Design
Preclinical
Follow-up
20 minutes (up to 24 hours in a subset)
Authors
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Amygdala cryoblockade may prevent ischemia-induced VF; hypothesis-generating for neuromodulation in arrhythmia prevention.
Does bilateral cryoblockade of the amygdala prevent ventricular fibrillation in psychologically stressed pigs during acute myocardial ischemia?
Bilateral cryoblockade of the amygdala prevents ventricular fibrillation during acute myocardial ischemia in a porcine model, highlighting the role of the paleomammalian brain in fatal arrhythmogenesis.
Carpeggiani et al. (1992) studied this question.
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