Key result
Felodipine cuts VF by ~100% versus control in pigs after coronary artery ligation.
Why the study?
Does felodipine prevent ventricular fibrillation after coronary artery ligation in anaesthetized pigs?
Does felodipine prevent ventricular fibrillation after coronary artery ligation in anaesthetized pigs?
In a porcine model of acute coronary ischemia, felodipine effectively prevented initial ventricular fibrillation and reduced ectopic activity, though its efficacy diminished upon subsequent occlusion.
Answers are grounded in this paper and cite their sources.
Should not change clinical practice; leaves open translation of antiarrhythmic effects to human acute coronary syndromes.
A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranolol-treated animals. Felodipine (10 nmol kg-1) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.
No takes yet. Share an insight, caveat, or question.
Verdouw et al. (1983) studied Ventricular fibrillation after coronary artery ligation. Felodipine vs. Control and propranolol was evaluated on Ventricular fibrillation (VF). Felodipine (10 nmol kg-1) completely abolished ventricular fibrillation after coronary artery ligation in anaesthetized pigs.
Synapse has enriched 10 related papers. Consider them for comparative context: