Transition-Metal-Catalyzed Hydrosulfoximination and Oxidation Reaction for the Synthesis of Sulfoximine Derivatives

We report herein a Au/Ag-cocatalyzed chemoselective hydrosulfoximination reaction of simple ynamides with free NH-sulfoximines, which produces the N-alkenylated sulfoximidoyl derivatives with quantitative atom efficiency and good to excellent yields. Further elaborations of the enamine isomers under Ru-catalyzed oxidative conditions to cleave the C═C double bonds can selectively afford urea-type sulfoximines. The aforementioned catalytic reactions provide new opportunities for the convergent and straightforward access to sulfoximine derivatives.