February 1, 1995Neurology
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ϵ4 allele
Key result
APOE ε4 allele linked to decreased hippocampal volume asymmetry in nondemented elderly subjects.
Why the study?
Does the APOE ε4 variant affect hippocampal atrophy and volume asymmetry on MRI in elderly subjects and those with dementia?
Population
Patients with Alzheimer's disease, Lewy body dementia, and nondemented elderly subjects
Design
Systematic_review
Authors
Discussion
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Implication
APOE ε4 may subtly alter hippocampal morphology on MRI without immediate clinical implications; extends observational links in nondemented elderly but leaves predictive value open.
Structured PICO
Does the APOE ε4 variant affect hippocampal atrophy and volume asymmetry on MRI in elderly subjects and those with dementia?
P
Population
Patients with Alzheimer's disease, Lewy body dementia, and nondemented elderly subjects
I
Intervention
APOE ε4 variant
O
Outcome
Hippocampal atrophy and volume asymmetry on MRIsurrogate
This systematic review evaluates the relationship between the APOE ε4 variant and hippocampal atrophy on MRI in dementia and nondemented elderly subjects.
Cite This Study
Soininen et al. (1995) studied this question. The apolipoprotein E ϵ4 allele is associated with decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects.