What question did this study set out to answer?

Identify and map chromosomal loci responsible for genetic variation in susceptibility and survival following Trypanosoma brucei brucei infection.

June 7, 2011PLoS neglected tropical diseasesOpen Access

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

View Full Paper

Ask AI

Bookmark

Authors

MŠMatyáš Šíma HHHelena Havelková LQLei Quan

Discussion

Member takes

Overview

Genetic mapping study uncovers four loci controlling survival in Trypanosoma brucei brucei–infected mice, highlighting specific chromosomal regions that influence parasite susceptibility.

Key Points

Identify and map chromosomal loci responsible for genetic variation in susceptibility and survival following Trypanosoma brucei brucei infection.
Assessed survival after T. b. brucei infection across recombinant congenic (RC) strains from the BALB/c-c-STS/A (CcS/Dem) series, identifying hypersensitive strain CcS-11.
Genotyped STS-derived segments across eight chromosomes in F2 hybrid mice generated from a BALB/c and CcS-11 cross.
Evaluated linkage between marker genotypes and survival duration using analysis of variance.
Mapped four Trypanosoma brucei brucei response (Tbbr) loci controlling survival, with Tbbr1 (chromosome 3) and Tbbr2 (chromosome 12) showing significant main effects.
Identified an epistatic gene-gene interaction governing survival between Tbbr3 on chromosome 7 and Tbbr4 on chromosome 19.
Fine-mapped Tbbr2 to a 2.15 Mb genomic interval harboring only 26 candidate genes.

Cite This Study

Šíma et al. (2011) studied this question.

synapsesocial.com/papers/6aa862c37fa1fa2c8282b747 https://doi.org/10.1371/journal.pntd.0001173

View Full Paper

Ask AI

Bookmark

June 7, 2011PLoS neglected tropical diseasesOpen Access

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

View Full Paper

Ask AI

Bookmark

Authors

MŠMatyáš Šíma HHHelena Havelková LQLei Quan

Discussion

Member takes

Overview

Genetic mapping study uncovers four loci controlling survival in Trypanosoma brucei brucei–infected mice, highlighting specific chromosomal regions that influence parasite susceptibility.

Key Points

Identify and map chromosomal loci responsible for genetic variation in susceptibility and survival following Trypanosoma brucei brucei infection.
Assessed survival after T. b. brucei infection across recombinant congenic (RC) strains from the BALB/c-c-STS/A (CcS/Dem) series, identifying hypersensitive strain CcS-11.
Genotyped STS-derived segments across eight chromosomes in F2 hybrid mice generated from a BALB/c and CcS-11 cross.
Evaluated linkage between marker genotypes and survival duration using analysis of variance.
Mapped four Trypanosoma brucei brucei response (Tbbr) loci controlling survival, with Tbbr1 (chromosome 3) and Tbbr2 (chromosome 12) showing significant main effects.
Identified an epistatic gene-gene interaction governing survival between Tbbr3 on chromosome 7 and Tbbr4 on chromosome 19.
Fine-mapped Tbbr2 to a 2.15 Mb genomic interval harboring only 26 candidate genes.

Cite This Study

Šíma et al. (2011) studied this question.

synapsesocial.com/papers/6aa862c37fa1fa2c8282b747 https://doi.org/10.1371/journal.pntd.0001173

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark