Key result
Paracetamol exposure reduces zebrafish embryo survival, causing pericardial edema, spinal abnormalities, and lower heart rates.
Why the study?
Paracetamol misuse is increasingly prevalent and can cause serious health issues including heart damage, prompting investigation into its impact on development using zebrafish embryos.
Paracetamol exposure induces significant dose- and time-dependent developmental toxicity, including cardiac abnormalities, in zebrafish embryos.
Paracetamol may pose early developmental cardiac risks; animal data leave human relevance open, requiring clinical confirmation.
The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.
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Putri et al. (2023) studied this question. Paracetamol was evaluated on Hatching and survival rates, and developmental abnormalities. Paracetamol exposure negatively affected hatching and survival rates in zebrafish embryos, causing spinal abnormalities, pericardial edema, and reduced heart rate.
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