Key result
Autonomic dysfunction severity in early Parkinson's strongly correlates with nonmotor symptoms and poorer quality of life.
Population
1,746 patients with recent onset Parkinson's disease, mean age 67.6 years, 65.2% male.
Design
Cohort
Authors
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Screening for autonomic symptoms may be warranted even in recent-onset PD; leaves open their causal impact on motor severity, NMS, and quality of life.
Cohort (n=1,746)
Yes
Effect estimate: ρ = 0.717
p-value: p=<0.001
Autonomic dysfunction is common in early Parkinson's disease and correlates with other nonmotor symptoms and worse quality of life.
Malek et al. (2016) conducted a cohort in Early Parkinson's disease (n=1,746). Autonomic dysfunction was evaluated on Correlation of autonomic dysfunction severity with other nonmotor symptoms (ρ = 0.717, p=<0.001). In early Parkinson's disease, autonomic dysfunction severity strongly correlates with other nonmotor symptoms (ρ=0.717, P<0.001) and poorer quality of life (ρ=0.483, P<0.001).
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