Key result
Anthraquinones stimulate skeletal muscle calcium release via direct interaction with the ryanodine receptor complex.
Population
Skeletal muscle sarcoplasmic reticulum (SR) vesicles and chemically skinned psoas muscle fibers
Design
Preclinical
Authors
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No immediate clinical application; leaves open cardiac ryanodine receptor effects and human translation.
Anthraquinones stimulate calcium release from skeletal muscle sarcoplasmic reticulum through direct interaction with the ryanodine receptor complex.
Abramson et al. (1988) studied this question. Anthraquinones (doxorubicin, mitoxantrone, daunorubicin, rubidazone) was evaluated on Calcium release from skeletal muscle sarcoplasmic reticulum. Anthraquinones stimulate calcium release from skeletal muscle sarcoplasmic reticulum via direct interaction with the ryanodine receptor complex and sensitization of the calcium activator site.
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