Novel drug-polymer conjugates were prepared by chemical immobilization of hydrazides on poly (N-vinyl pyrrolidone-alt-itaconic anhydride) support. Hydrazides with tuberculostatic activity were synthesized as derivatives of N-(p-nitrobenzoyl)-L-glutamine. Elemental and spectral analysis confirmed the chemical structure of the newly synthesized compounds and the evaluation of biological activity showed an increase of the tuberculostatic effect and a lower toxicity by chemically linking the hydrazides onto co-polymer.
No takes yet. Share an insight, caveat, or question.
Grebinişan et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: