Key result
Highly conserved LIM-homeobox genes regulate tissue differentiation and neural patterning across diverse organisms.
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LIM-homeobox genes have conserved functions in tissue and neural patterning across diverse organisms.
Homeobox genes play fundamental roles in development. They can be subdivided into several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of LIM-homeobox genes has been remarkably conserved through evolution. Have their functions similarly been conserved? A host of new data has been derived from mutational analysis in diverse organisms, such as nematodes, flies and vertebrates. These studies have revealed a prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date. Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements.
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Hobert et al. (2000) reported a review. LIM-homeobox genes was evaluated. LIM-homeobox genes are highly conserved through evolution and play a prominent role in tissue patterning and differentiation, particularly neural patterning, across diverse organisms.
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