February 1, 1996Genes & DevelopmentOpen Access

Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ.

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Key result

LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes, exhibiting marked selectivity in their interactions in situ.

Population

Cellular environment analyzing LIM motifs (MLP, CRP, and betaCRP)

Design

Preclinical

Authors

SASilvia ArberUniversity of Basel PCPico CaroniNovartis (Switzerland)

Discussion

Member takes

Implication

Preclinical LIM motif data warrant no clinical changes; leaves open targeted human studies in myogenic differentiation.

Structured PICO

Population

Cellular environment analyzing LIM motifs (MLP, CRP, and betaCRP)

Intervention

Analysis of LIM motifs and constructs (MLP, CRP, betaCRP)

Outcome

Binding properties and subcellular localization of LIM motifs

LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes, with specific roles in cytoskeleton association and myogenic differentiation.

Cite This Study

Arber et al. (1996) studied this question. LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes, exhibiting marked selectivity in their interactions in situ.

synapsesocial.com/papers/6a0cc4d004164ea96334c2ee https://doi.org/10.1101/gad.10.3.289

View Full Paper

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February 1, 1996Genes & DevelopmentOpen Access

Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ.

View Full Paper

Ask AI

Bookmark

Key result

LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes, exhibiting marked selectivity in their interactions in situ.

Population

Cellular environment analyzing LIM motifs (MLP, CRP, and betaCRP)

Design

Preclinical

Authors

SASilvia ArberUniversity of Basel PCPico CaroniNovartis (Switzerland)

Discussion

Member takes

Implication

Preclinical LIM motif data warrant no clinical changes; leaves open targeted human studies in myogenic differentiation.

Structured PICO

Population

Cellular environment analyzing LIM motifs (MLP, CRP, and betaCRP)

Intervention

Analysis of LIM motifs and constructs (MLP, CRP, betaCRP)

Outcome

Binding properties and subcellular localization of LIM motifs

LIM motifs function as specific adapter elements to promote the assembly and targeting of multiprotein complexes, with specific roles in cytoskeleton association and myogenic differentiation.

Cite This Study

synapsesocial.com/papers/6a0cc4d004164ea96334c2ee https://doi.org/10.1101/gad.10.3.289

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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