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No immediate clinical implications; extends the map of LIM-kinase interactions for targeted cardiovascular research.
LIM domains are double zinc-finger motifs that mediate protein interactions between transcription factors, cytoskeletal and signaling proteins. This review outlines the protein interactions mediated by LIM domains with signaling proteins including tyrosine and serine/threonine kinases and phosphatases.
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Brown et al. (2001) studied this question.
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