Key result
Ldb1 binds LIM domains through its carboxyl-terminal region, forms homodimers via its amino-terminal region, and synergizes with Xlim-1 to activate downstream genes in animal explants.
Population
Frog embryo microinjection and animal explant models
Design
Preclinical
Authors
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Ldb1's modular interactions with LIM proteins extend developmental transcription models in explants; leaves open any clinical relevance to human disease.
Ldb1 interacts with LIM domains and synergizes with Xlim-1 to activate downstream genes, likely by recruiting other transcriptional activators.
Breen et al. (1998) studied this question. Ldb1 and Xlim-1 interaction was evaluated on Protein-protein interactions and transcriptional activation. Ldb1 binds LIM domains through its carboxyl-terminal region, forms homodimers via its amino-terminal region, and synergizes with Xlim-1 to activate downstream genes in animal explants.
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