Key result
The LIM/double zinc-finger domain of human cysteine-rich protein (hCRP) mediates efficient homodimerization, which depends on the coordination of two zinc atoms.
Population
In vitro and cell-based models studying human cysteine-rich protein
Comparison
Mutagenesis and fusion constructs of the… vs Wild-type vs mutant constructs
Design
Preclinical
Authors
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Does not support clinical translation; extends zinc-finger roles to homodimerization but leaves open human relevance.
The LIM/double zinc-finger motif functions as a specific protein dimerization domain, expanding the known roles of zinc-finger motifs beyond DNA/RNA binding.
Feuerstein et al. (1994) studied this question. LIM/double zinc-finger domain was evaluated on Protein dimerization ability. The LIM/double zinc-finger domain of human cysteine-rich protein (hCRP) mediates efficient homodimerization, which depends on the coordination of two zinc atoms.
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