THE PATTERN of behavior which is shown by the white rat at the time of estrus is composed of the copulatory response given on stimulation by the male (Stone, 1922; Hemmingsen, 1933; Ball, 1937; Blandau, Boling and Young, 1941), often a male-like mounting activity (Long and Evans, 1922; Hemmingsen, 1933; Beach, 1938; Beach and Rasquin, 1942; Ball, 1940), and a greatly increased running activity (Wang, 1923; Slonaker, 1924; Hemmingsen, 1933). The latter behavior has been induced in spayed females by treatment with a variety of naturally occurring estrogens and synthetic substances having estrogenic properties (Bugbee and Simond, 1926; Wang, cited by Richter, 1927; Hemmingsen, 1933; Richter, 1934; Richter and Hartman, 1934; Hemmingsen and Krarup, 1937) and, although the amount of activity following treatment did not always equal that shown prior to ovariectomy (Bugbee and Simond, 1926; Slonaker, 1927; Hemingsen, 1933; Hemmingsen and Krarup, 1937), the opinion is held generally that the running activity associated with estrus is stimulated bythe ovarian estrogens or their metabolites.
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Young et al. (1945) studied this question.