Key result
Longer KCNN3 CAG repeats are linked to schizophrenia in the Serbian population.
Case-Control (n=101)
Longer CAG repeats in the KCNN3 gene are associated with schizophrenia in the Serbian population.
Suggests KCNN3 variants may influence schizophrenia risk in select populations; hypothesis-generating and requires replication before any clinical consideration.
KCNN3 might be a candidate gene for schizophrenia. The KCNN3 cDNA sequence contains two stretches of CAG trinucleotide repeats encoding two separate polyglutamine segments near the N-terminus of this channel protein. The second CAG repeat is highly polymorphic in the Caucasian population from both Europe and United States. The authors carried out a study to compare the allelic frequency distribution of the CAG repeat in KCNN3 gene in 55 Serbian schizophrenic patients and 46 controls. The data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia in the Serbian population.
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Ivković et al. (2006) conducted a case-control in Schizophrenia (n=101). Longer CAG repeats in second polymorphic KCNN3 region vs. Controls was evaluated on Allelic frequency distribution of the CAG repeat in KCNN3 gene. Longer CAG repeats in the second polymorphic KCNN3 region were significantly associated with schizophrenia in the Serbian population.
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