Endocrine Disruption and Perspective Human Health Implications: A Review

Over the last decades, many tone of man made chemicals have been produced and released into the environment. Many of these environmental contaminants have the ability to modulate the action of hormones by interacting with hormone receptors and mimic or antagonize the production and activities of endogenous hormones are called endocrine disruptors. The public health implications of these so called endocrine disruptors have been the subject of scientific debate, media interest and policy attention over the past several years. In this article we review the background of environmental endocrine disruption, developmental effects due to early exposure of Endocrine disrupting compounds (EDCs), assessing mode of action of endocrine disruptors, disruption of female hormonal function and its potential effects, and current evidence of possible impacts on reproduction system and neurobehavioral function. Finally, worldwide health policy activities that are relevant to endocrinedisrupting compounds in the environment are discussed.