Key result
L-arginine partly abolishes postprandial endothelial impairment and uncouples flow-mediated vasodilation from triglycerides.
Why the study?
Postprandial endothelial dysfunction occurs due to oxidative burden from triglyceride-rich lipoproteins reducing nitric oxide bioavailability, and its modulation by L-arginine is unclear.
Does oral L-arginine administration improve postprandial endothelial function in young healthy males?
Comparison
Before vs after 10 days of oral L-arginine administration following standardized oral fat load
Design
Interventional study measuring flow-mediated vasodilation and biochemical markers
Follow-up
10 days
Authors
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Should not change practice; leaves open whether L-arginine mitigates postprandial endothelial impairment in at-risk groups.
Does oral L-arginine administration improve postprandial endothelial function in young healthy males?
Oral L-arginine supplementation may partially attenuate postprandial endothelial dysfunction induced by a fat load in healthy young men.
Marchesi et al. (2001) studied Healthy volunteers (n=7). L-arginine vs. Baseline (before L-arginine) was evaluated on Endothelial function (flow-mediated vasodilation of the brachial artery). L-arginine administration partly abolished postprandial endothelial impairment, uncoupling flow-mediated vasodilation from triglycerides (r=-0.12, P=0.52 vs baseline r=-0.426, P=0.024).
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