Key result
Vitamin D <20 ng/ml linked to higher total cholesterol and LDL-C in obese children.
Why the study?
Vitamin D deficiency is reported in obese children and is associated with dyslipidemia and increased cardiovascular risk in adulthood.
Is Vitamin D insufficiency associated with an unfavorable lipid profile in obese children?
Observational (n=120)
Is Vitamin D insufficiency associated with an unfavorable lipid profile in obese children?
Vitamin D insufficiency in obese children is associated with an unfavorable lipid profile, including elevated total cholesterol and LDL-C.
Answers are grounded in this paper and cite their sources.
May support lipid monitoring in obese children with low vitamin D; hypothesis-generating for supplementation trials.
Vitamin D (25OHD) deficiency is reported in obese children. Low 25OHD levels are associated with dyslipidemia and increased risk of cardiovascular complication in adulthood. Within an observational study, 120 obese subjects in pediatric age were enrolled: 59 had 25OHD <20 ng/ml (group A) while 61 had 25OHD >20 ng/ml (group B). Group A versus Group B showed elevated total cholesterol (TC), p = 0.017, low-density lipoprotein cholesterol (LDL-C), p = 0.045, and parathormone (PTH), p = 0.008. Apolipoprotein B (ApoB) showed a similar trend, p = 0.074. Negative correlations were found between 25OHD and the following parameters: TC (ρ = -0.22, p = 0.01), LDL (ρ = -0.22; p = 0.03), ApoB (ρ = -0.20; p = 0.03), and PTH (ρ = -0.33, p = 0.003). No differences in High Lipoprotein Cholesterol (HDL-C) were found. In multivariate regression the most powerful predictor for explaining 25OHD variation were TC (p = 0.048) and PTH (p = 0.055). Within a pediatric obese population an association between 25OHD low levels and unfavourable lipid patterns has been found.
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Rusconi et al. (2015) conducted an observational in Obesity (n=120). Vitamin D (25OHD) <20 ng/ml vs. Vitamin D (25OHD) >20 ng/ml was evaluated on Total cholesterol (TC) (p=0.017). Vitamin D levels <20 ng/ml in obese children were associated with elevated total cholesterol and LDL-C compared to levels >20 ng/ml.
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