Lipoxygenase Pathways as Mediators of Early Inflammatory Events in Atherosclerosis

xidative modification of low density lipoproteins has been a leading hypothesis in atherogenesis, and throughout the 1990's there was intense interest in the discovery of pathways leading to this modification.1,2 In a commentary to an article dealing with 12/15-lipoxygenase gene disruption in the atherosclerotic apolipoprotein E (apoE)-deficient mouse model in 1999, Daniel Steinberg declared "at last direct evidence that lipoxygenases play a role in atherosclerosis."3,4 Since this article seven years ago, the lipoxygenase pathway involvement in atherogenesis has become rather more complicated.