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September 1, 2026Journal of Biomedical Materials Research Part B Applied Biomaterials

Clinical and Histological Evaluation of Porcine Urinary Bladder Matrix and Artificial Dermis in the Treatment of Tendon/Bone Exposed Wounds

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Authors

BYBo YuanGXGang XuCDChengliang Deng

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Overview

Case series reveals porcine urinary bladder matrix enhances vascularization and tissue regeneration in tendon- and bone-exposed wounds, highlighting its potential over standard artificial dermis.

Key Points

  • To compare clinical, histological, and transcriptomic regenerative efficacy between porcine urinary bladder matrix and artificial dermis in extremity wounds with exposed bone or tendon.
  • Evaluated a clinical case series of 6 extremity wound cases involving tendon or bone exposure treated with either porcine urinary bladder matrix (ExceFil) or artificial dermis (Pelnac).
  • Assessed wound bed vascularization, skin graft survival, tissue histology at 15 ± 2 days post-implantation, and gene expression profiles via RNA sequencing.
  • Both dermal substitutes promoted wound vascularization and successful skin graft integration across treated extremities.
  • Urinary bladder matrix led to superior histological outcomes, demonstrating accelerated fibroblast migration, increased collagen deposition, robust neovascularization, and elevated M2 macrophage polarization at 15 ± 2 days post-implantation.
  • RNA sequencing demonstrated significant upregulation of cytokine-cytokine receptor interaction and chemokine signaling pathways within the urinary bladder matrix group.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6aa87ccbded45317cb59fd24https://doi.org/10.1002/jbm.b.70156
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