Study of the influence of the composition of a cream for topical therapy of foot mycosis on its consistency properties

The study of new effective medicines is focused on the study of 1,2,4-triazole derivatives, given their high potential. Scientists have repeatedly proved that 2-(((3-(2-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)phenol reveals significant antifungal activity against different types of fungi. The purpose of the work is to evaluate the composition of the cream with 2-(((3-(2-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)phenol to update data on its structurally structural and mechanical properties and forecasting of the optimal composition for further preclinical studies. The material of the study was the topical dosage form of 2-(((3-(2-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)phenol on the emulsion based type of oil/water, which determines the optimal pharmacotechnological properties of this pharmacotherapeutic, as well as carriers. The consistant properties of the compositions were evaluated using the Rotational Viscosimeter «Reotest-2». The estimate of the ratio of effective viscosity and shift speed showed that the values are directly proportional. The predominant location of the structural and mechanical properties of the cream with 2-(((3-(2-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)phenol is established by phenol 0.01% and Its basicsю in the area of rheological optimum consistency of the cream, which along with the small value of «mechanical stability» (1.74) the studied system confirms the absolute dominance of coagulation in it, which have the ability to regenerate after destruction. This makes it possible to vary in terms of choice of homogenization equipment for the production of dosage form, the intensity of its processing, as well as anticipation during storage of basic structural and mechanical properties. Practical absence of differences in the values of «mechanical stability» of cream with 2-(((3-(2-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)imino)methyl)phenol 0.01% But the carrier allows to predict the minimization of the possibility of interaction between the existing and excipients of the dosage form. The possibility of positive quantitative distribution on the surface of the skin during therapy and appropriate technological operations in the production of dosage form was detected on the basis of the calculation and analysis of the coefficients of the dynamic course of the dosage form (Kd1 = 29%; Kd2 = 67%).