Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction
Key result
Frailty linked to ~232% greater 6-month mortality risk in MI patients.
- HR 3.32
- 95% CI 2.30-4.79
- n=3,381
Why the study?
Data on the prognostic value of frailty to guide clinical decision-making for patients with myocardial infarction are scarce.
Is frailty associated with increased 6-month mortality in patients after acute myocardial infarction?
Population
3381 MI patients with frailty assessed using CFS-9 in SWEDEHEART
Comparison
Frail (CFS 5-9) and vulnerable non-frail (CFS 4) vs non-vulnerable non-frail (CFS 1-3)
Design
Observational multicentre study with retrospective analysis of prospectively collected registry data
Follow-up
6-month
Authors
Discussion
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Member takes
Implication
Supports frailty screening post-MI for prognostication; leaves open whether interventions targeting frailty improve outcomes.
Study Design
Type
Observational (n=3,381)
Multicenter
Yes
Structured PICO
Is frailty associated with increased 6-month mortality in patients after acute myocardial infarction?
P
Population
3,381 patients with myocardial infarction assessed for frailty using the Clinical Frailty Scale, followed for 6 months.
E
Exposure
Frail (CFS 5-9) or vulnerable non-frail (CFS 4) status
C
Comparator
Non-vulnerable non-frail (CFS 1-3) status
O
Outcome
6-month mortalityhard clinical
Main Result
Hazard Ratio: 3.32 (95% CI 2.3–4.79)
Frailty assessed by the Clinical Frailty Scale is strongly and independently associated with 6-month mortality in patients after acute myocardial infarction.
Cite This Study
Ekerstad et al. (2021) conducted an observational in myocardial infarction (n=3,381). Frailty (CFS 5-9) vs. Non-frailty (CFS 1-3) was evaluated on 6-month mortality (HR 3.32, 95% CI 2.30-4.79). Frailty was independently associated with a higher risk of 6-month mortality compared with non-frailty in patients with myocardial infarction (HR 3.32; 95% CI 2.30-4.79).