N‐Sulfanylethylanilide Peptide as a Crypto‐Thioester Peptide

Native chemical ligation: N-sulfanylethylanilide (SEAlide) peptides act as thioester peptides in the presence of N-terminal cysteinyl peptides and an appropriate choice of salts. With the use of the SEAlide peptide, a kinetically controlled native chemical ligation proceeding in an unprecedented highly selective manner was achieved. Additionally, a one-pot, four-component coupling under kinetic conditions was achieved.