Key result
Early gestation skeletal muscle sequentially expresses at least three slow twitch myosin heavy chain isoforms.
Population
Human and rat skeletal muscle (fetal, neonatal, and adult stages)
Design
Preclinical
Authors
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Does not support clinical practice changes; leaves open functional roles of sequential slow MHC isoforms in human muscle development.
The identification of three sequentially expressed slow myosin heavy chain isoforms during development suggests they play an important role in determining skeletal muscle fiber function.
Hughes et al. (1993) studied Developing mammalian skeletal muscle. At least three isoforms of slow twitch myosin heavy chain are sequentially expressed during early gestation in human and rat skeletal muscle.
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