What does this research mean for the field?

Released adenosine diphosphate (ADP) specifically stabilizes thrombin-induced human platelet aggregates and prevents their deaggregation by inhibitors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1990Blood

Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates

Q: What is the clinical evidence from this study?

Study design: Other. Population: delta-storage pool deficiency. Intervention: Adenosine diphosphate (ADP) vs. Control platelets / no ADP. Primary outcome: Platelet deaggregation response to hirudin, chymotrypsin, and PGE1.

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Key result

Released ADP stabilizes thrombin-induced platelet aggregates, preventing their deaggregation by inhibitors.

Why the study?

The role of released ADP in stabilizing thrombin-induced human platelet aggregates and its mechanism of action was unclear.

Population

Normal human platelets, delta-storage pool deficiency platelets, and platelets from a patient with ADP sensitivity impairment

Comparison

Thrombin-induced aggregation with and without inhibitors and exogenous ADP or other agents

Design

Preclinical experimental study

Authors

MCMarco CattaneoVascular Medicine MCMT CancianiOspedale L. Bonomo ALAnna LecchiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Discussion

Member takes

Implication

May guide ADP-targeted antiplatelet development; leaves open translation from in vitro aggregates to clinical thrombosis.

Structured PICO

Population

Normal human platelets, platelets from patients with delta-storage pool deficiency (delta-SPD), and platelets from a patient (V.R.) with severe, selective impairment of sensitivity to ADP.

Intervention

Thrombin-induced aggregation and subsequent exposure to deaggregating inhibitors (hirudin, chymotrypsin, and prostaglandin E1) with or without exogenous ADP, serotonin, apyrase, CP/CPK, or epinephrine.

Comparator

Normal platelets vs delta-SPD platelets vs V.R. platelets; presence vs absence of exogenous ADP or other agents.

Outcome

Platelet deaggregation responsesurrogate

This in vitro study demonstrates that released ADP plays a specific and crucial role in stabilizing thrombin-induced human platelet aggregates.

Cite This Study

Cattaneo et al. (1990) studied delta-storage pool deficiency. Adenosine diphosphate (ADP) vs. Control platelets / no ADP was evaluated on Platelet deaggregation response to hirudin, chymotrypsin, and PGE1. Released ADP stabilizes thrombin-induced human platelet aggregates, preventing their deaggregation by inhibitors, whereas platelets lacking releasable ADP or ADP sensitivity are readily deaggregated.

synapsesocial.com/papers/6aa88bea07a63bd9a5070cbb https://doi.org/10.1182/blood.v75.5.1081.bloodjournal7551081

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Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider