Preclinical study demonstrates preserved parotid gland radioprotection with combined WR-2721 and Ro-07-0582 in rats, indicating radiosensitizer compatibility with cytoprotectants.
The radioprotection of the rat parotid gland by WR-2721 alone (DMF, 2.4) was compared to the protection afforded when WR-2721 was given in combination with the hypoxic cell radiosensitizer Ro-07-0582 (DMF, 2.6). It was concluded that the radiosensitizer of malignant tumor cells Ro-07-0582 was compatible with and did not reduce the protection of normal tissue afforded by WR-2721.
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Sodicoff et al. (1979) studied this question.
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