Key result
Dobutamine-atropine stress echo accurately detects CAD but sensitivity drops to ~36% in concentric remodeling.
Why the study?
Does dobutamine-atropine stress echocardiography accurately detect coronary artery disease in patients with different patterns of left ventricular hypertrophy?
Population
386 patients undergoing multistage dobutamine-atropine stress echocardiography and diagnostic angiography…
Comparison
Dobutamine-atropine stress echocardiography vs Diagnostic angiography (reference standard)
Design
Cross-sectional
Authors
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Caution warranted interpreting negative results in concentric remodeling; leaves open need for prospective validation and alternative modalities.
Observational (n=386)
Does dobutamine-atropine stress echocardiography accurately detect coronary artery disease in patients with different patterns of left ventricular hypertrophy?
Dobutamine-atropine stress echocardiography is accurate for detecting coronary artery disease in most patients with left ventricular hypertrophy, but has poor sensitivity in the subset with concentric remodeling.
Smart et al. (2000) conducted an observational in Left ventricular hypertrophy and suspected coronary artery disease (n=386). Dobutamine-atropine stress echocardiography vs. Diagnostic angiography was evaluated on Detection of coronary artery disease (sensitivity, specificity, and accuracy). Dobutamine-atropine stress echocardiography accurately detected coronary artery disease (86% overall accuracy), but sensitivity was markedly reduced to 36% in patients with concentric remodeling.
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