Zingerone Protects the Tellurium Toxicity in the Brain Mitochondria of Rats

induce opening of the mitochondrial permeability transition (MPT), an inner mitochondrial membrane, voltage sensitive, non-selective ion channel which opens to pass large molecular weight solutes between the mitochondrial matrix and cytoplasm, enabling the inner membrane (which is normally impermeable) to become permeable, leading to a "large amplitude swelling" [6].Zingerone is an active principle of Zingiber officinale rhizome having good medicinal value.It has been reported to inhibit lipid peroxidation (LPO) and possess superoxide dismutase (SOD) like activity [7,8].Previous reports have shown that zingerone quickly metabolized in rats and humans, easily crosses blood-brain barrier, achieves good concentration in systemic circulation, and is eliminated from body within 6 h after oral administration [9,10].The brain is rich in polyunsaturated fatty acids and is much prone to oxidative stress.It is proposed that brain mitochondria are the main