Key result
Predictive model shows good discrimination for post-colectomy VTE risk to guide extended prophylaxis.
Why the study?
Conflicting risk factors for post-discharge VTE and unclear guidelines for post-discharge pharmacoprophylaxis after colectomy motivated this study.
What are the risk factors for 30-day post-discharge VTE after colectomy, and which patients benefit from extended pharmacoprophylaxis?
Population
77,823 patients who underwent colectomy in the ACS NSQIP from 2011 to 2015
Comparison
Patients with predicted post-discharge VTE risk ≥-5.00 vs lower risk patients
Design
Cohort study with logistic regression modeling and validation set
Follow-up
30-day post-discharge
Authors
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Risk model may guide selective extended VTE prophylaxis after colectomy; leaves open need for randomized validation before practice change.
Cohort (n=77,823)
Yes
What are the risk factors for 30-day post-discharge VTE after colectomy, and which patients benefit from extended pharmacoprophylaxis?
A logistic regression model based on clinical factors can identify post-colectomy patients at risk for post-discharge VTE who may benefit from extended pharmacoprophylaxis.
Beal et al. (2018) conducted a cohort in Post-discharge venous thromboembolism after colectomy (n=77,823). Risk factors for post-discharge VTE was evaluated on 30-day post-discharge VTE. A predictive model for 30-day post-discharge VTE after colectomy demonstrated good discrimination (AUC 0.68), suggesting patients with a risk score ≥-5.00 should receive extended prophylaxis.
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